Crowd-sourcing for scientific research

Computers are much better than most humans at some tasks (eg, remembering large amounts of information, tedious and routine processing of large amounts of data), but worse than many humans at others (eg, generating new ideas, spatial pattern matching, strategic thinking). Progress may come from combining both types of machine (humans, computers) in ways which make use of their specific skills.  The journal Nature yesterday carried a report of a good example of this:  video-game players are able to assist computer programs tasked with predicting protein structures.  The abstract:

People exert large amounts of problem-solving effort playing computer games. Simple image- and text-recognition tasks have been successfully ‘crowd-sourced’ through games, but it is not clear if more complex scientific problems can be solved with human-directed computing. Protein structure prediction is one such problem: locating the biologically relevant native conformation of a protein is a formidable computational challenge given the very large size of the search space. Here we describe Foldit, a multiplayer online game that engages non-scientists in solving hard prediction problems. Foldit players interact with protein structures using direct manipulation tools and user-friendly versions of algorithms from the Rosetta structure prediction methodology, while they compete and collaborate to optimize the computed energy. We show that top-ranked Foldit players excel at solving challenging structure refinement problems in which substantial backbone rearrangements are necessary to achieve the burial of hydrophobic residues. Players working collaboratively develop a rich assortment of new strategies and algorithms; unlike computational approaches, they explore not only the conformational space but also the space of possible search strategies. The integration of human visual problem-solving and strategy development capabilities with traditional computational algorithms through interactive multiplayer games is a powerful new approach to solving computationally-limited scientific problems.”

Seth Cooper et al. [2010]: Predicting protein structures with a multiplayer online gameNature, 466:  756–760.  Published:  2010-08-05.
Eric Hand [2010]:  Citizen science:  people powerNature 466, 685-687. Published 2010-08-04.
The Foldit game is here.

0 Responses to “Crowd-sourcing for scientific research”

  • No Comments

Leave a Reply

You must be logged in to post a comment.